The Researches

RESEARCH FUNDS/GRANTS by Dr Javad Parvizi

Parvizi (PI) Post-Market Clinical Follow-up of the Zimmer Vivacit-E Highly Crosslinked Polyethylene Liner Used with the Continuum Acetabular Shell.

Zimmer (10/1/2013-2023)

Parvizi (PI) Prospective randomized clinical trial assessing post-operative wound healing complications following total joint arthroplasty using BandGrip Micro-Anchor Skin Closure compared to standard wound closure.

PSI Research Institute (2020-current)

Parvizi (PI) An Open-Label Study to Evaluate Tissue Distribution, Plasma Pharmacokinetics, Safety, and Tolerability after a sing Intravenous Dose of TNP-2092 in Adult Participants Undergoing Primary Total Hip or Knee Arthroplasty.

TenNor Therapeutics (2020-2022).

Parvizi (Co-I) Does PICO reduce surgical site infections after revision total joint arthroplasty?

Smith and Nephew (3/2016-2020)

Parvizi (PI) The Use of Barbed Sutures in Total Hip Arthroplasty: A Prospective, randomized, and controlled clinical trial

Ethicon (6/2016-2021).

Parvizi (Co-PI) Management of pain following total knee replacement surgery.

National Endowment for the Arts (2020-2022).

Kurtz S (PI), Rimnac C, Garino J, Hozack WJ, Purtill JJ, Sharkey PS, Parvizi J (site PI). Mechanics and Performance of Traceable UHMWPE.

National Institute of Health (R01-AR047904); (9/15/2010-07/23/2019)

Parvizi (PI) A prospective randomized comparative study to assess the prevention of surgical site infections in revision total joint arthroplasty patients treated with single use negative pressure wound therapy (PICO) or standars care dressing (Aquacel Ag Sugical Dressing

Smith and Nephew (12/2015-12/2018).

Parvizi, J (PI). Evaluation of In-vivo Wear of Ceramic Femoral Head against Highly Cross-Linked Polyethylene: A Comparative Study.

Ceramtec (November 2011- Ongoing)

Parvizi (PI) Multicenter Trial of the Continuum Ceramic Bearing System in Total Hip Arthroplasty.

Zimmer (08/05/2010-12/2016)

Parvizi (Co-I) An Open-Label, Non-Randomized, Single-Arm, Multi-Center Study to Evaluate Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for whom Chronic Antibiotic Suppressive Therapy is Indicated.

CEM-102 Pharmaceuticals, Inc (12/2015-1/12/2017).

Parvizi (PI) Evaluation of bacterial burden and biofilm formation on orthopaedic implant surfaces.

Lima (4/2016-2018)

Parvizi (PI) Bacterial Colonization with and without iodophor-impregnated adhesive drapes in hip surgery; a prospective, randomized, multicenter trial.

3M Corporation (06/2014-7/2016)

Parvizi (PI): Development and Evaluation of a Preoperative Periprosthetic Joint Infection Risk Calculator.

Pfizer (10/2014-12/2015)

Parvizi (PI). The Influence of A Natural Anti-Inflammatory Product on Levels of Inflammatory Markers in Cases with Osteoarthritis of the Knee

Physician Recommended Neutriceuticals (6/2014-7/2016)

Parvizi (PI)/Hickok/Adams (PI). A new allograft that promotes long-term, infection-free skeletal repair.

R01 DE 019901-01A1 12/1/2009-11/30/2011

Parvizi (PI)/Hickok (PI). Creating an Infection-Free Intraosseus Transcutaneous Amputation Prosthesis.

1R01 HD061053-01. 8/10/09- 7/31/12

Parvizi (PI). Serum molecular markers: a potential guide for reimplantation after resection arthroplasty for periprosthetic join tinfection.

Orthopedic Research and Education Foundation. July 2013-July 2016

Parvizi, J (PI). Use of PlasmaBlade leads to reduced necrosis of tissues during surgical dissection compared to conventional cauterization following unilateral total knee replacement.

(January 2012-March 2015)

Parvizi (PI) A Pivotal, Multicenter, Double-Blind Study of te Safety and Effectiveness of Synvisc-One (hylan G-F 20) in Patients with Mild to Moderate Primary Osteoarthritis of the Hip

Genzyme (06/2014-12/2014).

Parvizi J (PI) Evaluation of the Clinical Utility of the Cobas MRSA/SA Test for Detection of Staphylococcus Aureus and Methicillin Resistant Staphylococcus Aureus from Nasal Swabs.

Roche Molecular Systems (7/1/2013-10/1/2013)

Parvizi, J (PI), Harwood, M, Vitanzo, P. A Phase II Study to Determine the Efficacy and Safety of Allogeneic Human Chondrocytes Expressing TGF- β1 in Patients with Grade 3 Chronic Degenerative Joint Disease of the Knee

(09/01/2011-July 2014)

Jungkind D, Wang Z, Parvizi J. A Prospective Study Comparing the Performance of the Detect-Ready MRSA (Methicillin Resistant Staphylococcus Aureus) Kit with a Standard Reference Culture Method in Subjects at Risk for Nasal MRSA Colonization.

Molecular Detection, Inc. (Jan 2010-Sept 2014)

Parvizi J (PI). Diagnosis of PJI: Development of a point-of-care diagnostic tool for PJI through the identification of signature molecular markers.

Orthopedic Research and Education Foundation 2010-2013

Parvizi, J (PI). A Prospective, Randomized, Controlled, Single Blinded, Multicenter Study to Evaluate the efficacy and safety of Floseal for hemostatis in Primary, Unilateral Total Knee Arthoplasty (TKA).

Baxter (09/14/11-2/29/2013).

Parvizi J (PI). An open-label, randomized, multicenter Phase IIIb study to assess the efficacy, safety, and tolerance of BERIPLEX P/N compared with plasma for rapid reversal of coagulopathy induced by coumarin derivatives in subjects requiring emergency surgery or invasive diagnostic intervention.

CSL Behring (9/1/08-2011).

Parvizi, J (PI). A Prospective, Controlled, Pilot Study to Determine the Methodology of Microbial Skin Testing and to Determine the Contribution of 3M Ioban Antimicrobial Incise Drape to the Prevention of Surgical Field Contamination on Healthy Volunteer s in a Simulated Surgical Procedure.

3M Corporation. (03/24/11-2/2/2013).

Parvizi, J (PI). Multi-Center Trial of the Continuum Ceramic Bearing System in Total Hip Arthroplasty.

Zimmer, Inc. (08/05/10- 10/30/2011).

Parvizi J (PI). Prospective, Randomized Clinical Study to Evaluate the Efficacy of 2 Surgical Skin Preparations in Reducing Wound Drainage Following Total Joint Arhtroplasty.

3M Corporation. (2/11/10-12/30/2011)

Shapiro IM (PI), Parvizi J , Ducheyne P, Hickok N, Adams CW, Wickstrom E, Zieller A, Compasto R. Smart Substrates for New Generation of Implants.

National Institute of Health; (R01 AR051303)(8/1/05-7/31/10). Bioengineering Research Partnership

Parvizi J (PI). Trial to Evaluate Ultrasound in the Treatment of Tibial Fractures.

Smith and Nephew (8/18/08-9/1/11)

Parvizi J (PI). Hip Fracture Evaluation with Alternatives of Total Hip Arthroplasty versus Hemi-Arthroplasty (HEALTH). A multi-center Randomized Trial Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Revision Surgery and Quality of Life in Patients with Displaces Femoral Neck Fractures.

National Institute of Health (11/10/09-07/01/2010)

Parvizi J (PI) A Phase 2a, Randomized, Double-Blind, Placebo-and Active-Controlled, Parallel-Group, Multicenter Study Evaluating the Analgesic Efficacy and Safety of ADL5859 and ADL5747 in Subjects with Moderate to Severe Pain Due to Osteoarthritis of the Knee.

Adolor Corporation (10/21/2010-4/1/2011).

Parvizi J. (PI) Smart Substrates for New Generation of Implants.

National Institute of Health(K-08 AR051541-01 A1); (4/1/2005-3/31/2010)

Parvizi J (PI). A phase 2 randomized study investigating the safety, efficacy, and pharmacokinetics of Daptomycin versus comparator in the treatment of subjects undergoing surgical standard of care for osteomyelitis associated with an infected prosthetic joint caused by methicillin-resistant staphylococcus aureus and/or coagulase egetive staphylococci.

Cubist (6/30/07-12/30/09)

Parvizi J (PI). Allograft-associated infection: Prevention by antibiotic modification.

Musculoskeletal Transplant Foundation.1/1/2008-12/31/2009(extended)

Parvizi J (PI). The influence of Integuseal on postoperative wound drainage (Investigator Initiated Study).

Kimberly Clark (11/20/2007-4/30/09)

Parvizi J (PI). An open-label, multiple-dose, multiple-day, non-randomized, single arm safety study of repeat doses of DIC075V (intravenous diclofenac sodium) in patients with acute post-operative pain.

Javelin Pharmaceuticals, Inc. (10/1/08-3/30/09)

Alavi (PI). Parvizi J (Site PI). FDG-PET and FDG-PET/CT- Imaging in Painful Joint Prosthesis Study.

NIH R01 AR 3452425 (1/1/2005-12/30/09)

Ducheyne P (PI), Radin S, Shapiro IM, Parvizi J. Design of prosthesis with analgesic properties.

Center for Nanotechnology (3/1/07-6/30/09)

Adams CW (PI), Hickok N, Wickstrom EA, Adams CW, Composto R, Ducheyne P, Zieller A, Shapiro IM, Rothman RH, Parvizi J. Antibiotic and growth factor tethering of titanium surface.

Thomas Jefferson University (TJU) (1/1/05-12/31/07)

Parvizi J (PI). A multi-center, double-blind, randomized, placebo controlled study of the efficacy and safety of Paragablin in the treatment of subjects with post-operative pain following total knee arthroplasty (TKA)

Pfizer (6/30/2007-6/30/2008)

Viscusi (PI), Parvizi J. A Phase 2, Multicenter, Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Study to Evaluate the Tolerability, Safety, and Pharmacokinetics of 4975 in Patients Undergoing Primary Unilateral Total Knee Arthroplasty.

Anesiva (9/1/2007-1/30/2008)

Parvizi J (PI), Adams CW, Shapiro IM. Protein Expression in Fracture Callus after Ultrasound Stimulation Role of Mechanical Stimulation of Fracture Healing.

Smith and Nephew (8/1/2004-7/30/2007)

Parvizi (PI), Steinbeck M, Freeman T, Ries M, Rand J, Scully S, Spanghel M, Sharkey PF. Molecular mechanism of arthrofibrosis.

Aircast Foundation (1/1/06-12/30/07)

Hickok N, Parvizi J (I), Wickstrom EA, Adams CW, Composto R, Ducheyne P, Zieller A, Shapiro IM (PI). Orthopedic Implants Engineered to Prevent Postoperative Infection of Open Fractures.

Department of Defense (PMRP 17-03-1-0713); (1/1/04-12/31/07)

Parvizi J (PI), Flomenberg P. Efficacy of Linazolid in treatment of MRSA soft tissue infections.

Pfizer (4/1/05-4/30/07)

Parvizi J (PI), Pulido L, Hozack WJ, Sharkey PF, Purtill JJ, Austin MA. The efficacy of Celecoxib in improving postoperative pain and rehabilitation following total knee arthroplasty

(9/15/06-6/1/07)

Viscusi ER (PI), Parvizi J. The safety and efficacy of Methadone in postoperative pain management.

Parvizi J (PI). Smart Implants with Modified Biological Surface.

Orthopedic Research and Education Foundation-Clinician Scientist Award (1/1/04-12/31/06)

Parvizi, Williams M (PI), Furlong J. Use of Factor X-a (Odiparcel) in prevention of TED after total joint arthroplasty. GSK (5/11/2005-4/30/2006) Parvizi (PI), Viscusi G, Tarity TD. Natural history of pain following total joint arthroplasty.

Ortho McNeill (1/1/06-3/30/06).

Parvizi (PI), Purtill JJ. Use of Aprotinin in total joint arthroplasty.

Bayer (5/1/2005-10/22/2005)

Parvizi J (PI), Steinbeck MJ, Rand J., Ries M, Scully S, Saleh KJ, Sharkey PF. Reactive Oxygen Species May Mediate Arthrofibrosis Following Total Knee Arthroplasty.

American Knee Society (2004-2005)

Parvizi (PI), Ballas M, Schmit M. Role of Procrit in Reducing Blood Transfusion Needs after Unilateral TKA.

OrthoBiotech (2/1/2005-8/30/2005)

Parvizi J (PI), Purtill JJ. Arresting Hemostasis in Surgical Trauma Application.

Medafor Inc. (3/1/2004-2/28/2005)

Parvizi J (PI). Postoperative Bowel Dysfunction Following Total Joint Arthroplasty.

Glaxo Smith Klein (GSK) (1/8/04-6/30/2005)

Hozack WJ (PI), Parvizi J. Revision Hip Arthroplasty Using Restoration Modular System.

Stryker Orthopedics (7/1/2004-1/30/2005)

Parvizi J. (Mentor) Smart Implants in Orthopedic Surgery.

Orthopedic Research and Education Foundation Mentor Award (Student John N. Thomas III) (August 2004).

Viscusi E (PI), Parvizi J. Comparison of Safety and Efficacy of Patient Controlled Analgesia Delivered by Fentanyl HCI Transdermal System Versus IV Morphine Pump After THA.

OrthoMcNeil 2004

Parvizi (PI). Role of Refocoxib in Acute Pain Control Following Total Knee Arthroplasty.

Merck, Co. (1/1/2004-3/30/2004).

Parvizi J (Mentor). Reactive Oxygen Species May Mediate Arthrofibrosis Following Total Knee Arthroplasty.

Orthopedic Research and Education Foundation Mentor Award (Student Leah Bernstien) (August 2003).

Parvizi J (I). TGF-B Stimulation of Rabbit Periosteal Explants.

Mid-America Orthopaedic Association (8/1/2000-7/31/2001)

Parvizi J (PI). Role of Mechanical Stimulation in Fracture Healing.

Medical Research Council, UK (8/1/1997-7/31/1998)

Saleh K (PI, Parvizi (Center PI). Efficacy of Revision Total Knee Arthoplasty (North American Knee Arthroplasty Revision)(PI: K Saleh,

University of Minnesota)(OREF)

The Researches

RESEARCH FUNDS/GRANTS by Dr Javad Parvizi

We are are a click away from you